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What to know about oxycodone

What to know about oxycodone

What to know about oxycodone ,Oxycodone is a type of pain-relieving medication that doctors may prescribe to help people manage moderate to severe pain.

Oxycodone is an opiate (narcotic) analgesic. Opiate analgesics change how the brain and central nervous system respond to pain. These chemical changes stop a person from feeling pain in the same way as they did.

This article looks at the uses, dosage, and drug interactions of oxycodone. It also discusses the risks of using oxycodone and oxycodone addiction.

What is oxycodone used for?

oxycodone tablet pills spilling out of prescription opioid bottle.

A doctor may prescribe oxycodone to treat chronic pain when over-the-counter medications do not help.

Oxycodone can relieve moderate to severe acute pain. It is most useful for spontaneous bursts of shooting pain, also known as paroxysmal pain.

Doctors often prescribe oxycodone for:

  • paroxysmal pain
  • steady pain
  • allodynia, or a clinically sensitive pain response
  • chronic pain
  • cancer-related pain

How to take oxycodone

Oxycodone is available in a number of forms, including:

  • liquid
  • concentrated solution
  • tablet
  • capsule

People take all forms of oxycodone orally, meaning by mouth. A doctor will advise a person what dose of oxycodone to take and how often.

It is essential to follow a doctor’s instructions carefully. They will determine the correct amount of oxycodone for an individual to take, and a person must not exceed this or take the drug more frequently than stated on their prescription.

It is best to carefully measure out liquid forms of oxycodone to avoid taking too much.

Depending on why they are taking it, a person can use oxycodone for short- or long-term pain relief. Again, it is important only to take oxycodone for as long as the doctor prescribes.

Some oxycodone capsules and tablets are extended-release, meaning they release the medication over a longer time than other types.

If a person feels nauseous, it may help to take oxycodone with food.

More young women are having heart attacks

More young women are having heart attacks, unaware of the threat they face

The study, published in the journal Circulation on Tuesday, found heart attack cases among young people at hospitals in the U.S. rose from 27 per cent between the years of 1995 to 1999 to 32 per cent in 2010 to 2014, CNN report. There was a larger increase among women.

The study found younger women made up 31 per cent of hospitalizations for heart attacks, an increase of 21 per. Cent since the 90s. Buy Pain Meds Online Overnight

READ MORE: Heart disease in women is under-diagnosed, under-treated and under-researched: Heart and Stroke report

Cindy Yip, director of heart health at the Heart & Stroke Foundation, told Global News this trend is similar in Canada. Buy Oxycodone Online Overnight

Barriers for women

Other research from the foundation has found women, in general, are under-researched, under-diagnosed and under-treated as well as under-supported.

READ MORE: Stroke in young Canadians is on the rise, Heart & Stroke warns. Here’s why

The foundation found heart disease clinical research mostly focuses on men, even though men and women have different experiences when it comes to heart disease.

“I thought, this could not be a heart attack,” Sherlock told the site. “I am too young and healthy.”

Sherlock went to the hospital. “Within a few hours, I was in surgery and getting two stents to save my life,”

READ MORE: Women more likely to survive heart attacks if treated by a female doctor: study

Yip said the best thing young women can do to protect themselves is to be aware of their risks. Some risks include high blood pressure, smoking, excessive drinking, poor eating habits, and an inactive lifestyle.

A new generation of pain medication

A new generation of pain medication

Universitätsmedizin Berlin and the Zuse Institute Berlin have developed a new generation of pain medication. The researchers used computer simulations to develop new opioids that will only work at sites affected by injury or inflammation. These drugs can prevent the occurrence of brain- and gut-related side effects typically associated with conventional opioids and have been proven successful in preclinical studies. Results from this research have been published in Pain and Scientific Reports.

Opioids are a class of drugs with powerful pain-relieving properties. They are mainly used to treat the pain associated with and inflammation, such as that caused by surgery or cancer. Common side effects associated with their use include drowsiness, nausea, constipation, dependency and, in some cases, respiratory arrest. The research team, led by Dr. Christoph Stein of the Department of Anesthesiology and Surgical Intensive Care Medicine on Campus Benjamin Franklin, are hoping to develop new types of pain medications that will work without producing dangerous side effects. Collaborating with Dr. Marcus Weber of the Zuse Institute Berlin, the researchers used computer simulations to develop two new opioids. In both cases, the researchers used fentanyl as the starting molecule.

The researchers hypothesized that tissues that are damaged or inflamed show stronger interaction between  agonists—the substances that elicit the -relieving effect—and the  they bind to. Their computer simulations suggested that this is due to an increased concentration of protons in inflamed tissues, which leads to lower pH values than in healthy tissues, resulting in acidic conditions. Opioid molecules need to undergo protonation before they can bind to and activate opioid receptors. The researchers used this knowledge to design two drugs that would only exist in their protonated state in the presence of inflammation. This restricts opioid receptor activation to sites of tissue damage or inflammation, rather than receptors in the brain or gut.

“Our innovative design method provides a robust basis for a new generation of ,” reports Prof. Stein. He adds: “These drugs could help us both to avoid the dangerous side effects of conventional opioids and to reduce complications. They would also help us stem the opioid crisis, a problem that is particularly evident in the United States.”

The researchers hope to further develop these newly designed drugs in order to make them available to patients. They also plan to enhance their understanding of the molecular processes underlying the complex interactions seen in inflamed tissues, in the hope that they may be able to support opioid optimization through the insights they gain. Ideally, their insights will also be beneficial for other drugs, such as those used to treat high blood pressure.

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